Inter-Organ Communication

In this article we aim for a comprehensive review of many gene variants of PGC-1a gene that have been discovered by our and other groups. We have learned that they give PGC-1 an ability to adapt its functionality to specific tissues and stimuli.

When exercising, our muscles take the brunt of the effort. In order to cope with increased demands, molecular pathways orchestrated by PGC-1 gene are activated. The changes however don't stop there, so we decided to have a closer look on how exercised muscle affects the rest of the body.